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KMID : 1123920060200061598
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 6 p.1598 ~ p.1603
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Anti-inflammatroy Activity of YHJST in Activated Mast Cells
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Kim Sang-Hun
Koo Young-Sun
Jin Mi-Rim
Kim Dong-Hee
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Abstract
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Activated mast cells play pivotal roles in allergic and non-allergic inflammatory responses through the release of inflammatory mediators such as histamin, cysteinyl leukotriens, pro-inflammatory cytokines as well as chemokine. We tested whether YHJST, which is clinically prescribed for the treatment of various inflammatory disease including allergic disease, modulate inflammatory reactions in activated mast cells. YHJST decreased the release of histamine and b-hexosamidase in pholbol-12-myristate 13-acetate and/or calcium ionophore A23187 stimulated HMC-1 and RBL-2H3 cells, respectively. Further, the gene expressions of tumor necrosis factor-a, IL-6 and IL-8 were significantly reduced by YHJST. YHJST suppressed powerful induction of NF-kB promoter-mediated luciferase activity. Taken together, these data suggested that YHJST showed it’s anti-inflammatory effects through the down-regulation of mast cell activation.
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KEYWORD
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YHJST, Mast cell, Inflammatory mediators, NF-kB
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